TGA-Approved GRP Monoclonal Antibody Infusion Therapy

A new anti-calcitonin gene related peptide antibody therapy has shown efficacy in the preventative treatment of chronic migraine. The medication is distinctive compared to other CGRP antibody therapy in that it is administered by intravenous infusion, and reaches maximum plasma concentration in about 30 minutes, corresponding to the end of the infusion.

The medication is also unique in that a recent study indicates that this infusion therapy may provide benefits within hours of the infusion, with more frequently resolved acute migraine pain compared to placebo.

Patients with migraine have previously had to wait several weeks for the effect of their preventative medications to manifest, often resulting in extended periods of pain and reduced functioning, with potential visits to emergency departments to obtain migraine relief, and risk of overuse of acute medication.

Treatment with the iv infusion more frequently resolved headache pain at 2 hours compared to placebo. Additional studies have shown the magnitude of the benefit observed at day 1 was sustained over the 12 week dosing interval.

The data would suggest therefore that the new intravenous therapy has the potential to address both the acute and preventative treatment needs of patients with migraine. It raised the potential of being both an effective treatment preventing future attacks of migraine, with the added benefit of alleviating an acute migraine attack.

References

  1. Winner PK, McAlister P, Chakhava G et al Effects of Intravenous Eptinezumab vs Placebo on Headache Pain and most Bothersome Symptom when initiated during a Migraine attack A Randomised clinical trial, JAMA 2021, 325 (23) 2348-2356
  2. Lipton RB, Goadsby PJ, Smith J et al, Efficacy and safety of Eptinezumab in patients with chronic migraine PROMISE-2, Neurology 2020;94:e1365-e1377

Streamlined Assessment Headache Clinic.
No referral required!

Specialists in Headaches and Migraines led by Neurologists

1300 MYMIGRAINE
(1300 696 447)
07 3831 1611

Email us

Privacy Policy
Cancellation Policy

 

Address

St Andrew’s Place Level 2 Suite 312, 33 North Street Spring Hill 4000

Business Hours

Monday – Thursday 8.30am – 4pm
Friday 9.30am -2.30pm
Saturday, Sunday: Closed

Streamlined Assessment Headache Clinic. No referral required to see our GP (with special interest in migraine & headaches)!

ENQUIRE NOW

Specialists in Headaches and Migraines led by Neurologists


07 3831 1611

Email us

Privacy Policy
Cancellation Policy

Site by Roundhouse

Address

St Andrew’s Place Level 2 Suite 312, 33 North Street Spring Hill 4000

Business Hours

Monday – Thursday 8.30am – 4pm
Friday 9.30am -2.30pm
Saturday, Sunday: Closed

Privacy Settings
We use cookies to enhance your experience while using our website. If you are using our Services via a browser you can restrict, block or remove cookies through your web browser settings. We also use content and scripts from third parties that may use tracking technologies. You can selectively provide your consent below to allow such third party embeds. For complete information about the cookies we use, data we collect and how we process them, please check our Privacy Policy
Youtube
Consent to display content from Youtube
Vimeo
Consent to display content from Vimeo
Google Maps
Consent to display content from Google